The Clark is located on South Street, one-half mile south of the junction of Routes 2 and 7 in the center of Williamstown. The Clark is about three hours by car from Boston and New York City and about one hour from Lenox, Massachusetts, and Albany, New York. The Mohawk Trail (Route 2) provides scenic approaches from the east and west.
Nearby Albany International Airport is served by major airlines. The Albany-Rensselaer train station hosts regular Amtrak service from New York City. Bus service to Williamstown is also available from New York, Boston, and other New England cities.